Sections
Text Area
Publications @ Fei SUN Group
Find our group's papers via Google Scholar Link
- Fok HKF, Yang Z, Dai X, Yi Q, Che CM, Jiang L, Duan L, Huang J, Yang Z, Sun F. Red-Shifting B12-Dependent Photoreceptor Protein via Optical Coupling for Inducible Living Materials. [J]. Angewandte Chemie, 2024, 136(50): e202411105.https://doi.org/10.1002/ange.202411105
- Li, M., Huang, W., Duan, L., & Sun, F. (2024). Control Intracellular Protein Condensates with Light. ACS Synthetic Biology. https://doi.org/10.1021/acssynbio.4c00305
- Mendis, N. P., Yi, Q., Lee, J., Sun, F., & Lakerveld, R. (2024, October). A Precipitation-Based Purification Process of an Aflibercept Biosimilar. In 2024 AIChE Annual Meeting. AIChE.
- Fang, S., Li, Y., Kou, S., & Sun, F. (2024). Harnessing the Potential of Spider Silk Proteins for Biomedical Applications: from Native Silk Fibers to Designed Bioactive Materials. Advanced Functional Materials, 2419739. https://doi.org/10.1002/adfm.202419739
- Li, Y., Yang, C., Fang, S., Zhou, Y., Li, M., Liu, Z., ... & Sun, F. (2024). Clickable, Thermally Responsive Hydrogels Enabled by Recombinant Spider Silk Protein and Spy Chemistry for Sustained Neurotrophin Delivery. Advanced Materials, 2413957. https://doi.org/10.1002/adma.202413957
- Xu, L., Hu, P., Long, J., Wu, X., Ye, Y., Cui, N., Sun, F., Shen, J.,* and Long, D.* (2023) A Dual-Staining Method to Distinguish Retinal Vessels in Oxygen-Induced Retinopathy (OIR) Model. Journal of Clinical and Experimental Ophthalmology. Accepted.
- Jiang, B., Tan, S. Y., Fang, S., Feng, X., Park, B. M., Fok, H. K. F., ... & Sun, F. (2023). Designed multifunctional spider silk enabled by genetically encoded click chemistry. Advanced Functional Materials, 33(43), 2304143.https://doi.org/10.1002/adfm.202304143
- Kou, S., Chen, W., Sun, C., and Sun, F.* (2023) SpyStapler-mediated assembly of nanoparticle vaccines. Nano Research 16 (2), 2821-https://pubs.acs.org/doi/10.1021/acsnano.4c07061
- Yi, Q., Dai, X., Park, B.M., Gu, J., Luo, J., Wang, R., Yu, C., Kou, S., Huang, J.,* Lakerveld, R.,* and Sun, F.* (2022) Directed Assembly of Genetically Engineered Eukaryotic Cells into Living Functional Materials via Ultra-High-Affinity Protein Interactions. Science Advances 8: eade0073. DOI: 10.1126/sciadv.ade0073
- Li, M., Park, B.M., Dai, X., Xu, Y., Huang, J. and Sun, F.* (2022) Controlling synthetic membraneless organelles by a red-light-dependent singlet oxygen-generating protein. Nature Communications 13 (1), 1-13. https://doi.org/10.1038/s41467-022-30933-0
- Yang, Z., Fok, H., Luo, J., Yang, Y., Wang, R., Huang, X. and Sun, F.* (2022) B12-induced reassembly of split photoreceptor protein enables photoresponsive hydrogels with tunable mechanics. Science Advances 8: eabm5482.DOI: 10.1126/sciadv.abm5482
- Alvina, M.J.,1 Wei, J.,*6 and Sun, F.* (2022) PETase gets hot. Chem Catalysis 2 (10), 2437-2439. DOI: 10.1016/j.checat.2022.09.033
- Fok, HKF., Yang, Z., Jiang, B.1 and Sun, F.* (2022) From 4-arm star proteins to diverse stimuli-responsive molecular networks enabled by orthogonal genetically encoded click chemistries. Polymer Chemistry 13, 2331-2339. DOI: 10.1039/D2PY00036A
- Wei, J., Xu, L., Wu, WH., Sun, F. and Zhang, WB.* (2022) Genetically engineered materials: Proteins and beyond. Science China Chemistry 1-11. https://doi.org/10.1007/s11426-021-1183-x
- Fok, HKF. and Sun, F.* (2022) B12-dependent photoreceptor protein as an emerging tool for materials synthetic biology. Smart Materials in Medicine 3, 297-303. https://doi.org/10.1016/j.smaim.2022.03.004
- 易琪昆; 孙晨博; 杨中光; 王日; 寇松姿; 李朝霞; 孙飞* (2022) 可基因编码点击化学在材料合成生物学中的应用. Synthetic Biology Journal, v. 3, March 2022, p. 1-19. DOI: 10.12211/2096-8280.2021-076
- Xu, L., Wang, X., Sun, F., Cao, Y., Zhong, C.* and Zhang, WB.* (2021) Harnessing proteins for engineered living materials. Current Opinion in Solid State and Materials Science 25 (1), 100896.
- Sun, F.* and He, C. (2021) Reaction: Engineer Biology for Uranium. Chem 7 (2), 274-275.
- Li, T., Wang, J., Zhu, S., Delmo, E.P., Sun, F., Zhang, L., Gu, M., and Shao, M.* (2021) Cu3PdxN nanocrystals for efficient CO2 electrochemical reduction to methane. Electrochimica Acta 371, 137793.
- Wei, X., Fang, C., Gong, B., Shao, X., Sun, F., Qian, J., and Lin, Y.* (2021) Time-dependent response of bio-polymer networks regulated by catch and slip bond-like kinetics of cross-linkers. Journal of the Mechanics and Physics of Solids 147, 104267.
- Jiang, B., Liu, X., Yang, C., Kou, S., Liu, K. and Sun, F.* (2020). Injectable, photoresponsive hydrogels for delivering neuroprotective proteins enabled by metal-directed protein assembly. Science Advances 6: eabc4824.
- Wang, R. and Sun, F.* (2020). Give Life to a Glue. Matter 3 (6), 1820-1822.
- Luo, J. and Sun, F.* (2020). Calcium-responsive hydrogels enabled by inducible protein-protein interactions. Polymer Chemistry 11, 4973-4977.
- Sun, F.* and Zhang, WB* (2020). Genetically encoded click chemistry. Chinese Journal of Chemistry 38 (8), 894-896.
- Yang, Z., Yang, Y., Wang, M., Wang, T., Fok, H.K.F., Jiang, B., Xiao, W., Kou, S., Guo, Y., Yan, Y., Deng, X., Zhang, W.-B. and Sun, F.* (2020). Dynamically Tunable, Macroscopic Molecular Networks Enabled by Cellular Synthesis of 4-Arm Star-like Proteins. Matter 2, 233-249.
- Cao, Y., Wei, X., Lin, Y. and Sun, F.* (2019). Synthesis of Bio-Inspired Viscoelastic Molecular Networks by Metal-Induced Protein Assembly. Molecular Systems Design & Engineering. DOI: 10.1039/C9ME00027E. (Invited for MSDE Emerging Investigators 2020 Special Issue).
- Kou, S., Yang, X., Yang, Z., Liu, X., Wegner, S.V. and Sun, F.* (2019). Cobalt-Cross-Linked, Redox-Responsive Spy Network Protein Hydrogels. ACS Macro Lett. 8, 773-778.
- Park, B.M., Luo, J. and Sun, F.* (2019). Enzymatic Assembly of Adhesive Molecular Networks with Sequence-Dependent Mechanical Properties Inspired by Mussel Foot Proteins. Polym. Chem. 10, 823-826.
- Wu, X.-L., Liu, Y., Liu, D., Sun, F. and Zhang, W.-B.* (2018). An Intrinsically Disordered Peptide-Peptide Stapler for Highly Efficient Protein Ligation Both in Vivo and in Vitro. J. Am. Chem. Soc. 140 (50), 17474-17483.
- Yang, Z., Kou, S., Wei, X., Zhang, F., Li, F., Wang, X.-W., Lin, Y., Wan, C.,* Zhang, W.-B.* and Sun, F.* (2018). Genetically Programming Stress-Relaxation Behavior in Entirely Protein-Based Molecular Networks. ACS Macro Lett. 7, 1468-1474.
- Liu, X., Yang, X., Yang, Z., Luo, J., Tian, X., Liu, K., Kou, S. and Sun, F.* (2018). Versatile Engineered Protein Hydrogels Enabling Decoupled Mechanical and Biochemical Tuning for Cell Adhesion and Neurite Growth. ACS Appl. Nano Mater. 1, 1579-1585.
- Luo, J., Liu, X., Yang, Z. and Sun, F.* (2018). Synthesis of Entirely Protein-Based Hydrogels by Enzymatic Oxidation Enabling Water-Resistant Bioadhesion and Stem Cell Encapsulation. ACS Appl. Bio Mater. 1, 1735-1740.
- Tyagi, A., Liu, X., Abidi, I.H., Gao, Z., Park, B.M., Zeng, X., Ou, X., Cagang, A.A., Zhuang, M., Hossain, M.D., Sun, F.* and Luo, Z.*5 (2018). Modular functionalization of crystalline graphene by recombinant proteins: a nanoplatform for probing biomolecules. Nanoscale 10, 22572-22582.
- Zhang, X.-J., Wang, X.-W., Da, X.-D., Shi, Y.-L., Liu, C., Sun, F., Yang, S. and Zhang, W.-B.* (2018). A Versatile and Robust Approach to Stimuli-Responsive Protein Multilayers with Biologically Enabled Unique Functions. Biomacromolecules 19 (3), 1065-1073.
- Wei, J., Wu, W., Wang, R., Yang, Z., Sun, F.* and Zhang, W.B.* (2018). B12-Dependent Protein Oligomerization Facilitates Layer-by-Layer Growth of Photo/Thermal Responsive Nanofilms. ACS Macro Lett. 7 (5), 514-518.
- Wu, X., Huang, W., Wu, W., Xue, B, Xiang, D., Li, Y., Qin, M., Sun, F., Wang, W.,* Zhang, W.-B.,* Cao, Y.* (2018). Reversible hydrogels with tunable mechanical properties for optically controlling cell migration. Nano Res. 11 (10), 5556-5565.
- Sun, F.* and Zhang, W.B.* (2017). Unleashing Chemical Power from Protein Sequence Space toward Genetically Encoded Click Chemistry. Chin. Chem. Lett. 28 (11), 2078-2084.
- Wang, R., Yang, Z., Luo, J., Hsing, I.M. and Sun, F.* (2017). B12-Dependent photo-responsive protein hydrogels for controlled stem cell/protein release. Proc. Natl. Acad. Sci. USA 114, 5912-5917. (Hong Kong Institute of Engineers Best Materials Paper in 2017).
- Kou, S., Yang, Z. and Sun, F.* (2017). Protein Hydrogel Microbeads for Selective Uranium Mining from Seawater. ACS Appl. Mater. Interfaces 9 (3), 2035-2039.
- Kou, S., Yang, Z., Luo, J. and Sun, F.* (2017) "Entirely Recombinant Protein-Based Hydrogels for Selective Heavy Metal Sequestration ", Polym. Chem. 8, 6158-6164.
- Kou, S., Cheng, D., Sun, F.* and Hsing, I.M.*5 (2016). Microfluidics and Microbial Engineering. Lab on a Chip 16 (3), 432-446. (Lab on a Chip Most Accessed Articles in 2016).
- Bedbrook, C.N., Kato, M., Kumar, S.R., Lakshmanan, A., Nath, R.D., Sun, F., Sternberg, P.W., Arnold, F.H. and Gradinaru, V.* (2015). Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins In Vivo. Chem. Biol. 22, 1108-1121.
- Sun, F., Zhang, W.B., Mahdavi, A., Arnold, F.H.* and Tirrell, D.A.* (2014). Synthesis of bioactive protein hydrogels by genetically encoded SpyTag-SpyCatcher chemistry. Proc. Natl. Acad. Sci. USA 111, 11269-11274.
Book Chapters
- Yang, Z. and Sun, F.* (2021) Self-Assembly and Genetically Engineered Hydrogels. Tunable Hydrogels: Smart Materials for Biomedical Applications 178, 169-196.
- Wang, R. and Sun, F.* (2021) The Spy that links: Creation of nonlinear protein architectures and materials using SpyTag/SpyCatcher chemistry. Methods in Enzymology - Linkers in Biomacromolecules 647, 283.
- Wang, R. and Sun, F.* (2020). Photoresponsive hydrogels. Photochemistry (Royal Society of Chemistry), 47, 379-403.
Research Grants
Our research is supported by numerous grants from prestigious funding bodies, including:
- National Natural Science Foundation of China (NSFC)
- Hong Kong Research Grant Council (RGC)
- Ministry of Science and Technology (MOST)
- Shenzhen Science and Technology Innovation Committee
- Croucher Foundation
Selected Presentations
- (Invited) 26/07/2023 Invited seminar talk titled “Engineering Biology for Materials” at the Division of Chemistry and Physical Technology, ShanghaiTech University, Shanghai, China.
- (Invited) 05/05/2023 Invited seminar talk titled “Engineer Biology for New Materials” in Chemical Biology Lecture Series, Southern University of Science and Technology, Shenzhen, China.
- (Invited) 10/03/2023 Invited seminar talk titled “Engineer Biology for New Materials” in Soft Matter Lecture Series, Peking University, Beijing, China.
- (Invited) 02/03/2023 Invited seminar talk titled “Engineer Biology for New Materials” in the School of Emergent Soft Matter, South China University of Technology, Guangzhou, China.
- (Invited) 02/12/2022 Invited speech titled “New Optogenetics Enabled by Cobalamins and Chlorophylls” at the 3rd AICHE Optogenetic Technologies and Applications Conference in Heidelberg, Germany.
- (Invited) 17/12/2022 Invited talk titled “Engineer Biology for New Materials” at NSFC-Beijing/Hong Kong Academic Exchange Center Symposium on Structural Biology and Proteomics.
- (Invited) 14/08/2022 Invited speech titled “Engineer Biology for New Materials” at the 14th Global Chinese Chemical Engineers Symposium, Guangzhou, China.
- (Invited) 13/08/2022 Invited speech titled “Engineer Biology for New Materials” at HKUST Symposium “Sustainable Living through SynBio”, Hong Kong SAR, China.
- (Invited) 23/06/2022 Invited seminar talk titled “From Materials Synthetic Biology to New Optogenetics” at the 9th Materials Synthetic Biology Forum, The 221th Academic Seminar of the Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
- (Invited) 07/04/2022 Invited seminar talk titled” Engineer Biology for New Materials” at the LKS Faculty of Medicine, School of Biomedical Sciences, the University of Hong Kong, Hong Kong SAR, China.
- (Invited) 24/02/2022 Invited seminar talk titled “Engineer Biology for New Materials” at the Department of Biomedical Engineering, the Chinese University of Hong Kong, Hong Kong SAR, China.
- (Invited) 04/12/2021 NSFC-RGC Mainland and Hong Kong Young Scholars Forum in Frontiers and Challenges in Chemical Biology in the University of Hong Kong, Hong Kong SAR, China.
- (Invited) 17/06/2021 Invited talk titled “Engineer Biology for New Materials” at Royal Society of Chemistry MSDE Symposium 2021: Frontiers in Molecular Engineering, UK.
- (Invited oral) 22/08/2019 Invited talk titled “Synthetic Biology Approaches Toward Diverse Biomaterials” at International Symposium on Functional Soft Materials, Nanjing, China. (Travel and accommodation were paid by the host).
- (Invited) 03/07/2019 College of Chemistry and Molecular Engineering seminar talk titled “Synthetic Biology Approaches Toward Diverse Protein Materials” in Peking University, China. (Travel and accommodation were paid by the host).
- (Invited oral) 28/06/2019 Invited talk titled “Synthetic Biology Approaches Toward Diverse Protein Materials” in Green Chemistry Conference, Harbin, China. (Accommodation was paid by the host).
- (Invited) 03/06/2019 Invited seminar talk titled “Synthetic Biology and Novel Protein Materials” in School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China. (Accommodation was paid by the host).
- (Invited oral) 20/04/2019 Invited talk titled “Synthetic Biology and Novel Protein Materials” in in the 4th Biotechnology Youth Forum, Chinese Society of Biotechnology, Shanghai, China.
- (Invited) 18/04/2019 Frontiers in Biological Sciences seminar talk titled “Unleashing Chemical Power from Protein Sequence Space for Material Design” in Tsinghua University, China. (Travel and accommodation were paid by the host).
- (Invited oral) 31/03/2019 Invited talk titled “Synthetic Biology Approaches Toward New Materials” in the East Lake Forum of Chemical Biology, Wuhan, China. (Accommodation was paid by the host).
- (Invited) 04/01/2019 Invited Seminar talk titled “Synthetic Biology Approaches Toward Diverse Protein Materials” in the School of Physical Science and Technology, ShanghaiTech University, Shanghai, China.
- (Invited) 25/12/2018 Seminar talk titled “Unleashing Chemical Power from Protein Sequence Space for Material Design” in the Department of Chemistry, Jinan University, China.
- (Invited) 27/11/2018 IAS Nobel Popular Science Lecture titled “Directed Evolution: Unleash Chemical Power from Protein Sequence Space” in the Jockey Club Institute of Advanced Study, HKUST.
- (Invited oral) 19-21/10/2018 Invited talk titled “Synthetic Biology Approaches Toward Diverse Protein Materials” in the 14th Bioinorganic Chemistry Conference, Chinese Chemical Society, Nanjing, China. (Accommodation was paid by the host).
- (Invited) 09/10/2018 Seminar talk titled “Unleashing Chemical Power from Protein Sequence Space for Material Design” in the Institute of Applied Physics and Materials Engineering, the University of Macau, China. (Travel and accommodation were paid by the host).
- (Keynote) 15-16/09/2018 Keynote speech titled “Synthetic Biology Approaches Toward Protein Materials” in the Forum on Construction Materials and Environmental Engineering, Yancheng, China. (Travel and accommodation were paid by the host).
- (Invited) 03/09/2018 Invited seminar talk titled “Unleashing Chemical Power from Protein Sequence Space for Material Design” in Ludwig Seminar series, the University of Oxford, UK. (Travel and accommodation were paid by the host).
- (Invited) 31/08/2018 Invited seminar talk titled “Unleashing Chemical Power from Protein Sequence Space for Material Design” in the Department of Chemistry, the University of Edinburgh, UK. (Accommodation was paid by the host).
- (Invited) 27/08/2018 Invited seminar talk titled “Unleashing Chemical Power from Protein Sequence Space for Material Design” at Max Planck Institute for Polymer Research, Mainz, Germany.
- (Invited oral) 07/07/2018 Invited talk titled “Synthetic biology approaches toward diverse protein materials” at 4th Synthetic Biology Young Scholar Forum (SynBioYSF), Shenzhen, China. (Travel and accommodation were paid by the host).
- (Invited oral) 28/05/2018 Invited talk titled “Synthetic biology approaches toward diverse protein materials” in the Symposium “Soft materials, including Biomaterial Engineering and Characterization”, 101st Canadian Chemistry Conference and Exhibition, Canadian Society for Chemistry, Canada. (Registration fee was waived).
- (Invited oral) 20-23/05/2018 Invited lecture at the Max Planck-Croucher Symposium 2018: The Future of Biology, held at Ringberg Castle in Kreuth/Tegernsee, Germany. (Travel and accommodation were paid by the host).
- (Invited oral) 05-08/05/2018 Invited talk titled “Synthetic Biology Approaches Toward Diverse Protein Materials” in the 31st Chinese Chemical Society Annual Congress, Hangzhou, China.
- (Invited) 20/04/2018 Invited speech titled “Synthetic Biology Approaches Toward Diverse Protein Materials” in “Innovature 2018 – Innovation for Future”, the Hong Kong Institution of Engineers, Hong Kong SAR, China.
- (Invited oral) 30/03/2018 Invited seminar talk titled “Genetically Encoded Click Chemistry: Unleashing Chemical Power from Protein Sequence Space for Designing New Material”, in the Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, China. (Travel and accommodation were paid by the host).
- (Invited) 12/12/2017 Invited seminar talk titled “Synthetic biology approaches toward diverse protein materials” in the Department of Chemistry, University of Hong Kong, Hong Kong SAR, China.
- (Invited) 08/12/2017 Invited seminar talk titled “Synthetic biology approaches toward diverse protein materials” in the Institute of Microbiology, CAS, Beijing, China. (Travel and accommodation were paid by the host).
- (Invited) 02/09/2017 Invited talk titled “Synthetic biology approaches toward protein soft materials” in the 2nd Symposium on Frontiers of Soft Matter Science and Engineering Youth Forum on Biomacromolecules, Peking University, China. (Travel and accommodation were paid by the host).
- (Invited) 26/05/2017 Invited CALM seminar talk titled “Synthetic biology approaches for protein materials” at Donghua University, Shanghai, China. (Travel and accommodation were paid by the host).
- (Invited) 12/05/2017 Invited seminar talk titled “Synthetic biology approaches for protein materials” at Max Planck Institute for Polymer Research, Mainz, Germany.
- (Invited oral) 11-12/03/2017 Invited talk titled “Synthetic biology approaches toward protein materials” at Asian Engineering Deans’ Forum on Bioengineering, National University of Singapore, Singapore.
- (Invited oral) 24/12/2016 Invited talk for “Overseas Scholars Visit to Top Chinese Universities” in Southeast University, Nanjing, China. (Travel and accommodation were paid by the host).
- (Invited) 09/12/2016 Invited seminar talk at Yancheng Institute of Technology, China. (Travel and accommodation were paid by the host).
- (Invited oral) 17/10/2016 Invited talk at the First Qilu Forum on Science & Technology, Shandong University, China. (Travel and accommodation were paid by the host).
- (Invited oral) 15/09/2016 The project titled “Microalgae for Uranium Mining from the Ocean (MUM)” was selected as one of the 10 top projects for the Google X Science Fair on September 15th 2016 in Mountain View, California (My entire team including two PG students and the supervisor was invited to present at the Google X headquarter). (Travel and accommodation were paid by the host).
- (Invited oral) 14/07/2016 Invited talk titled “Synthetic biology approaches toward diverse protein materials” at 2nd Synthetic Biology Young Scholar Forum (SynBioYSF) 2016 at Peking University, China. (Travel and accommodation were paid by the host).
- (Oral) 17-22/05/2016 Oral presentation in the 10th World Biomaterials Congress, Montreal, Canada.
- (Invited oral) 05/04/2016 Invited talk at the Max Planck Society – Croucher Foundation workshop on Molecular Systems Engineering Sciences, Hong Kong.
- (Invited oral) 05/12/2016 Invited talk at the Joint Symposium with Institute of Genetics and Developmental Biology, CAS, Hong Kong.
- (Invited) 21/12/2015 Invited Seminar talk titled “Genetically encoded click chemistry: unleashing chemical power from protein sequence space for materials design” in the School of Physical Science and Technology, ShanghaiTech University, Shanghai, China. (Travel and accommodation were paid by the host).
- (Invited) 20/08/2015 Invited talk at the one-day symposium “Bioengineering in the 21st Century”, the University of Hong Kong, Hong Kong SAR, China.
- (Invited) 27/06/2015 Invited seminar talk titled “Genetically encoded click chemistry: unleashing chemical power from protein sequence space for materials design” at Donghua University, Shanghai, China.
- (Invited oral) 20-23/04/2015 Oral presentation at IAS Focused Program on Biomaterials for Medical Applications, HKUST.
- (Invited) 29/12/2014 Invited seminar talk at the School of Chemistry and Chemical Engineering, Nanjing University, China. (Accommodation was paid by the host).
- (Invited oral) 11/09/2013 Oral presentation at Micro Mornings, Caltech, Pasadena, CA, USA.
- (Invited oral) 10-12/05/2013 Invited talk at the 1st Young Chemists Forum, Zhejiang University, Hangzhou, China. (Travel and accommodation were paid by the host).
- (Invited oral) 10-13/10/2010 Oral presentation at International Conference on Gram-Positive Pathogens, Omaha, Nebraska, USA. (Travel award was provided by the Organizer).
- (Invited oral) 07/03/2010 Oral presentation at NIH11th Annual NARSA Investigators Meeting, USA.